Integrated Lifestyle Modifications can bring a new hope for Prediabetic Indians – Study
Pune, 2nd September 2025: A study recently published (13th August 2025) in the Journal of Diabetes Research has shown that Integrated Lifestyle Modification with multidisciplinary approach can bring a new hope for prediabetic Indians. The study was conducted by the team of doctors at Pune based Freedom From Diabetes Institute. The team was led by Dr. Pramod Tripathi and included Dr. Diptika Tiwari, Dr.Nidhi Kadam, Dr.Anagha Vyawahare, Dr.Baby Sharma, Dr.Thejas Kathrikolly, Dr.Malhar Ganla, and Dr. Banshi Saboo.
The data for this study was extracted from 427 patients with prediabetes who were enrolled in the 1-year online integrated ILI program between March 2020 and May 2023 from 89 cities in India who met the eligibility criteria. The data included patients with HbA1C 5.7%- 6.4% not on insulin or oral hypoglycaemic agents and aged between 18-75 years. The intervention consisted of a personalized plant-based diet, physical activity, psychological support, and medical management.
At the end of the study, 47.1% of patients achieved prediabetes remission. Significant weight loss and improvements were observed in HbA1c, BMI, fasting blood glucose, fasting insulin, insulin resistance, lipid profile, and blood pressure. Notably, 34% of patients lost more than 10% of their body weight. Females achieved
greater reductions in weight and BMI than males.
Dr. Pramod Tripathi, Founder , Freedom from Diabetes said that prediabetes is a growing health concern in India with an estimated prevalence of about 15%. But it also offers a crucial window period for correcting our lifestyle. This retrospective study was aimed at assessing the effectiveness of an integrated intensive lifestyle
intervention. Prediabetes remission was achieved in almost half of the patients, highlighting the effectiveness of a tailored multidisciplinary approach for managing prediabetes in the Indian population. The study showed significant weight loss, improved glycaemic control, and better lipid profiles and emphasized the need
for personalized strategies for prediabetes management considering factors such as sex and BMI.
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Findings
At the end of the study, 47.1% of patients achieved prediabetes remission. Significant weight loss and improvements were observed in HbA1c, BMI, fasting blood glucose, fasting insulin, insulin resistance, lipid profile, and blood pressure (p < 0.05). Notably, 34% of patients lost > 10% of their body weight. Females achieved greater reductions in weight and BMI than males (p < 0.001). The BMI stratified analysis revealed higher remission rates in the obesity group (BMI ≥ 25 kg/m2) (49.9%) than in the nonobesity group (BMI 18–24.9 kg/m2) (37.0%) (p = 0.028). The obesity group showed greater improvements in glycemic parameters and insulin resistance than the nonobesity group (p < 0.05). Logistic regression identified age ≤ 50 years (OR: 2.15, 95% CI: 1.42–3.27), endline HOMA-IR < 2.5 (OR: 1.60, 95% CI: 1.01–2.45), and > 10% weight loss (OR: 3.72, 95% CI: 2.34–5.90) as significant factors associated with prediabetes remission.
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Founded in Pune, Freedom From Diabetes is a leading health organization dedicated to helping individuals achieve remission in diabetes and prediabetes through evidence-based lifestyle transformation since 2013. FFD has helped thousands achieve diabetes remission through its programs integrating diet, exercise, psychology, and medical care.
